Bipolar disorder (manic-depressive illness) is a mood disorder that involves episodes of both manic highs and seriously low mood swings, with periods of normalcy in between. The third most common mood disorder, Bi-polar depression is often severe and life threatening. It affects about 1% of adults during their lifetime. Symptoms of manic depression typically begin during adolescence or early adulthood, and continue to recur throughout life. Men and women are equally likely to develop this disabling illness. Manic depression is often complicated by co-occurring alcohol or substance abuse. Without effective treatment, bipolar illness leads to suicide in nearly 20% of cases. For more information on Symmetries mode of action please read the page on formulation.